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Osame, M., Janssen, R., Kubota, H., Nishitani, H., Igata, A., Nagataki, S., et al. (1990) Nationwide Survey of HTLV-I-Associated Myelopathy in Japan: Association with Blood Transfusion. Annals of Neurology, 28, 50-56.
https://doi.org/10.1002/ana.410280110

has been cited by the following article:

• TITLE: Dynamics of an HTLV-I Model Incorporating Viral Replication Delay and CTL Immunity

  AUTHORS: Yinji Huang

  KEYWORDS: HTLV-I Model, Viral Replication Delay, Stability, Hopf Bifurcation

  JOURNAL NAME: Journal of Applied Mathematics and Physics, Vol.13 No.8, August 26, 2025

  ABSTRACT: Human T-cell leukemia/lymphoma virus type I (HTLV-I) is a pathogenic retrovirus, and cytotoxic T lymphocytes (CTLs) or specific CD8+ cytotoxic T lymphocytes are considered crucial factors in the human immune system against viral infections. Therefore, studying the impact of CTL immune response on HTLV-I infection is essential. This paper investigates a class of HTLV-I infection models that consider latent infected CD4+ T cells and viral replication delay (the time from initial infection of healthy CD4+ T cells to becoming latent CD4+ T infected cells). By analyzing the model, the basic reproduction number for immunological inactivation R 0 and the basic reproduction number for immunological activation R 1 are defined. Using R 0 and R 1 as thresholds, the local stability of the infection-free equilibrium E 0 , the immunological inactivation equilibrium point E 1 , and the immunological activation equilibrium point E * is established by analyzing the distribution of roots of the corresponding characteristic equations when τ=0 . Additionally, the local stability for τ≠0 and the existence of Hopf bifurcations with delay as a bifurcation parameter are discussed.