TITLE:
Highly Efficient Synthesis of Novel Fluorine Bearing Quinoline-4-carboxylic Acid and the Related Compounds as Amylolytic Agents
AUTHORS:
Mohammed S. T. Makki, Dina A. Bakhotmah, Reda M. Abdel-Rahman
KEYWORDS:
Amylolytic Activity; Amylolytic Agents; Aspergillus fungi; Efficient Synthesis; Fluoroquinoline;Quinoline-4-carboxylic Acids
JOURNAL NAME:
International Journal of Organic Chemistry,
Vol.2 No.1,
March
15,
2012
ABSTRACT: Highly efficient syntheses of novel fluorine bearing quinoline-4-carboxylic acids and the related compounds had been achieved from cyclocondensation of 2-amino-5-fluorophenyl glyoxylic acid 1 with benzoyle asetanilides 2 in boiling DMF, to give the target 3. Decarboxylation of 3 produced 6-fluoro-2-phenyl-3-(substituted amino)-keto-quinolines 4, while that reaction underwent refluxing, afforded 7-fluoro-1-(aryl)-3-phenyl-pyrrolo[3,4-c] quinoline-2,9-diones 5. Structure of the products has been established from their elemental and spectral analysis. All targets exhibited a high to moderate activity against some Aspergillus fungi as amylolytic agents.