TITLE:
Paroxysmal Nocturnal Hemoglobinuria in Pregnancy (A Case Report)
AUTHORS:
Abrar Tooq, Bayan Al-Sayegh, Nusrat Kazi
KEYWORDS:
Paroxysmal Nocturnal Hemoglobinuria, Thrombocytopenia in Pregnancy, Eculizumab in Pregnancy
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.15 No.8,
August
20,
2025
ABSTRACT: Paroxysmal nocturnal hemoglobinuria (PNH) is a rare cause of hemolytic anemia that can be exacerbated by pregnancy. This case report reflects on this condition. A pregnant 27-year-old female, a known case of PNH, presented with a history of liquor drainage. Upon investigation, we found that her platelet levels were 75 × 109. The patient was following up with the hematology department, where they started her on eculizumab. PNH can induce thrombocytopenia in pregnancy, which can lead to thromboembolic events; the risk reaches 10% in pregnancy. Moreover, it can lead to an increased risk of infection, which also happened to our patient, as she presented with a labial abscess 5 months post-delivery. Conclusion: Pregnant women with PNH must have their platelet levels closely monitored to prevent thromboembolic events.