TITLE:
Advances in Biomarkers of Neonatal Hyperbilirubinemia
AUTHORS:
Qianshi Sun, Zixuan Ye, Tingting Wu, Qihong Fan
KEYWORDS:
Neonatal Hyperbilirubinemia, Bilirubin Encephalopathy, Biomarker
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.13 No.8,
August
19,
2025
ABSTRACT: Neonatal hyperbilirubinemia (NHB) is a common neonatal disease in clinical practice, and bilirubin encephalopathy caused by excessive free bilirubin across the blood-brain barrier causes irreversible neurological damage to the central nervous system, which is the most serious complication. Therefore, early prediction of NHB, early diagnosis, and intervention are significant to prevent the emergence of serious complications of NHB. In recent years, with the development of science and technology, molecular biology and genomics, a variety of novel biomarkers have been discovered and applied to the clinic. This article focuses on NHB-related biomarkers and also discusses the value of these biomarkers in disease prediction, diagnosis, prognosis assessment, and treatment monitoring, which will provide a reference for clinical practice and future research.