Article citationsMore>>

C.-J. Li, “Organic Reactions in Aqueous Media—With a Focus on Carbon-Carbon Bond Formation,” Chemical Reviews, Vol. 93, No. 6, 1993, pp. 2023-2035. doi:10.1021/cr00022a004

has been cited by the following article:

• TITLE: An Efficient Synthesis of Pyrido[2,3-d]pyrimidine Derivatives via One-Pot Three-Component Reaction in Aqueous Media

  AUTHORS: Shahrzad Abdolmohammadi, Saeed Balalaie

  KEYWORDS: Diammonium Hydrogen Phosphate (DAHP), Microwave Irradiation (MWI), Water in Organic Synthesis, Pyrido[2, 3-d]pyrimidine

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.2 No.1, March 15, 2012

  ABSTRACT: A series of pyrido[2,3-d]pyrimidines derivatives have been prepared by one-pot three-component reaction of 4(6)-aminouracil, malononitrile and aromatic aldehydes. This efficient synthesis was done under microwave irradiation conditions (method A) and also using catalytic amount of diammonium hydrogen phosphate [(NH4)2HPO4] (DAHP) in aqueous media (method B). This procedure has the advantages of good yields, easy work-up, and benign environmentally friendly character. Reaction could proceed via domino Knoevenagel-Michael-cyclization reactions.