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Uchinami, Y., Takikawa, S., Takashima, F., Maeda, Y., Nasu, S., Ito, A., et al. (2019) Incidence of Postoperative Nausea and Vomiting Is Not Increased by Combination of Low Concentration Sevoflurane and Propofol Compared with Propofol Alone in Patients Undergoing Laparoscopic Gynecological Surgery. JA Clinical Reports, 5, Article No. 70.
https://doi.org/10.1186/s40981-019-0292-4

has been cited by the following article:

• TITLE: Comparison of the Time to Orientation between Combining Propofol with Sevoflurane or Sevoflurane in Patients Undergoing Endoscopic Trans-Nasal Surgery: A Randomized Controlled Trial

  AUTHORS: Narin Plailaharn, Apinya Kittiponghansa, Waroonkarn Mahavisessin, Pichayen Duangthongphon, Thirada Jimarsa, Sangmukda Sara, Lumyai Sabangba, Cattleya Kasemsiri

  KEYWORDS: Propofol, Sevoflurane, Trans-Sphenoidal Surgery, Endoscopic Sinus Surgery, Functional Endoscopic Sinus Surgery (FESS)

  JOURNAL NAME: Open Journal of Anesthesiology, Vol.15 No.8, August 15, 2025

  ABSTRACT: Background: This study investigates whether combining propofol and sevoflurane for anesthesia maintenance results in faster emergence compared to sevoflurane alone in patients undergoing endoscopic trans-nasal surgery. Methods: Thirty-eight patients were randomized to receive either sevoflurane alone (Group S, n = 19) or propofol plus sevoflurane (Group PS, n = 19) targeting a BIS range of 40 - 60. The primary outcome was time to orientation. Secondary outcomes included time to spontaneous ventilation, eye-opening to sound, extubation, hemodynamics, agitation, coughing, analgesic needs, and PONV. Results: The median time to orientation was significantly longer in Group PS (12 minutes, IQR 6-16) compared to Group S (6 minutes, IQR 5-12) (P Conclusion: Using BIS-targeted anesthesia, combining propofol with sevoflurane resulted in a longer time to orientation than sevoflurane alone in patients undergoing endoscopic trans-nasal surgery, particularly when anesthesia exceeded 120 minutes.