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Wedzicha, J.A., Calverley, P.M.A., Albert, R.K., Anzueto, A., Criner, G.J., Hurst, J.R., et al. (2017) Prevention of COPD Exacerbations: A European Respiratory Society/American Thoracic Society Guideline. European Respiratory Journal, 50, Article ID: 1602265.
https://doi.org/10.1183/13993003.02265-2016

has been cited by the following article:

• TITLE: Therapeutic Role of Carbocysteine in Chronic Respiratory and Otorhinolaryngological Diseases: A Systematic Review and Meta-Analysis

  AUTHORS: Myriam Calle-Rubio, José Luis R. Martin

  KEYWORDS: Carbocysteine, Chronic Respiratory Disease, Mucoregulation, COPD Exacerbations, Otitis Media with Effusion, Meta-Analysis

  JOURNAL NAME: Open Journal of Respiratory Diseases, Vol.15 No.3, August 1, 2025

  ABSTRACT: Background: Carbocysteine is a mucoregulatory agent with anti-inflammatory properties used in chronic respiratory and otorhinolaryngological diseases. However, clinical evidence across indications remains heterogeneous. Methods: A systematic review and meta-analysis were conducted to assess the efficacy of oral carbocysteine in stable chronic conditions. PubMed, Cochrane Library, and ClinicalTrials.gov were searched up to February 2025. Eligible randomized controlled trials compared carbocysteine with placebo or standard treatments. Outcomes were meta-analyzed when reported in at least two studies. Results: Twenty RCTs were included. In COPD, a meta-analysis of incidence rates showed a pooled rate ratio of 0.48 (95% CI: 0.32 - 0.72; p Conclusions: Carbocysteine demonstrates consistent clinical benefits in COPD and otitis media with effusion. Further high-quality trials are warranted in other chronic indications.