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Rogers, C.A., Scott, L.J., Reeves, B.C., Downes, S., Lotery, A.J., Dick, A.D., et al. (2018) Serum Vascular Endothelial Growth Factor Levels in the IVAN Trial; Relationships with Drug, Dosing, and Systemic Serious Adverse Events. Ophthalmology Retina, 2, 118-127.
https://doi.org/10.1016/j.oret.2017.05.015

has been cited by the following article:

• TITLE: Intravitreal Injection of Bevacizumab Induced TMA: A Case Report

  AUTHORS: Nada Zagdouni, Mohamed Amine Khalfaoui, Benyounès Ramdani

  KEYWORDS: Vascular Endothelial Growth Factor (VEGF), Thrombotic Microangiopathy (TMA), Bevacizumab, Renal Toxicity, Intravitreal Injection

  JOURNAL NAME: Open Journal of Nephrology, Vol.15 No.3, July 25, 2025

  ABSTRACT: The use of vascular endothelial growth factor (VEGF) inhibitors, particularly anti-VEGF agents like Bevacizumab, has become a cornerstone in the treatment of proliferative diabetic retinopathy and diabetic macular edema. While systemic renal side effects of these agents are well-documented, emerging evidence suggests that intravitreal administration may also be associated with significant renal risks. We report the case of a 32-year-old male with a 25-year history of type 1 diabetes who developed thrombotic microangiopathy (TMA) following intravitreal Bevacizumab injections. Diagnostic evaluations ruled out other causes, leading to a diagnosis of drug-induced TMA. Treatment included corticosteroids and plasma exchange, but renal function did not recover, necessitating hemodialysis. This case underscores the critical need for renal monitoring in patients receiving anti-VEGF therapy, particularly those with preexisting renal impairment, to mitigate the risk of serious renal complications.