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Santacroce, E., D’Angerio, M., Ciobanu, A.L., Masini, L., Lo Tartaro, D., Coloretti, I., et al. (2024) Advances and Challenges in Sepsis Management: Modern Tools and Future Directions. Cells, 13, Article 439.
https://doi.org/10.3390/cells13050439

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• TITLE: Comparative Response of Immune System Activation in Patients in the Postoperative Period: A Study of Antibacterial Therapy versus Radonized Water from Tskaltubo

  AUTHORS: Zurab Shekiladze, Giorgi Gogiberidze, Davit Zurabashvili, Sofo Chikobava, Davit Natadze, Marine Nikolaishvili

  KEYWORDS: Radon Therapy, Mucosal Immunity, Immune Modulation, Cytokine Response, Postoperative Healing, Dental Implantation, Salivary Biomarkers, Antibiotic Effects, Tissue Regeneration

  JOURNAL NAME: Journal of Biosciences and Medicines, Vol.13 No.7, July 23, 2025

  ABSTRACT: Tskaltubo radon-rich mineral water produced a different immunological profile. While similarly effective in suppressing pathogenic flora, this intervention preserved and possibly enhanced the mucosal immune response. In Group 2, patients exhibited increased levels of interferon-gamma (IFN-γ) and interleukin-4 (IL-4), without a corresponding rise in proinflammatory cytokines such as IL-1 or IL-6. This indicates a measured activation of the immune system in response to surgical trauma. Most notably, IL-10 levels increased in this group, suggesting a heightened regulatory response and a more balanced immune environment conducive to controlled healing.