TITLE:
Comparative Response of Immune System Activation in Patients in the Postoperative Period: A Study of Antibacterial Therapy versus Radonized Water from Tskaltubo
AUTHORS:
Zurab Shekiladze, Giorgi Gogiberidze, Davit Zurabashvili, Sofo Chikobava, Davit Natadze, Marine Nikolaishvili
KEYWORDS:
Radon Therapy, Mucosal Immunity, Immune Modulation, Cytokine Response, Postoperative Healing, Dental Implantation, Salivary Biomarkers, Antibiotic Effects, Tissue Regeneration
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.13 No.7,
July
23,
2025
ABSTRACT: Tskaltubo radon-rich mineral water produced a different immunological profile. While similarly effective in suppressing pathogenic flora, this intervention preserved and possibly enhanced the mucosal immune response. In Group 2, patients exhibited increased levels of interferon-gamma (IFN-γ) and interleukin-4 (IL-4), without a corresponding rise in proinflammatory cytokines such as IL-1 or IL-6. This indicates a measured activation of the immune system in response to surgical trauma. Most notably, IL-10 levels increased in this group, suggesting a heightened regulatory response and a more balanced immune environment conducive to controlled healing.