TITLE:
Monoamine Oxidase Deficiency Symptom Management with Memantine: A Case Report
AUTHORS:
Mark C. Chandler, Nithya S. Burisetty
KEYWORDS:
Monoamine Oxidase, Brunner’s Syndrome, Memantine, Glutamate, Whole Exome Sequencing
JOURNAL NAME:
Case Reports in Clinical Medicine,
Vol.14 No.7,
July
17,
2025
ABSTRACT: A patient with developmental delays, agitation, disordered sleep, cataplexy and anxiety was recently diagnosed with monoamine oxidase deficiency using whole exome sequencing. The overactive monoamine system explained the symptom complex and suggested a pharmacological approach to reduce glutamate activity while avoiding monoamine stimulation. Memantine has helped this young man better benefit from active treatment in a community setting. Further exploration of the genetics and management of monoamine oxidase abnormalities is encouraged.