TITLE:
Platelet-Rich Plasma Injection into the Colorectal Anastomosis Reduces the Anastomotic Leakage Incidence: A Randomized Controlled Trial
AUTHORS:
Kenan Mohsen Sbh, Abdul Ghani Al Shalabi
KEYWORDS:
Colorectal Anastomosis, Anastomotic Leakage, Platelet-Rich Plasma, PRP, Low Anterior Resection
JOURNAL NAME:
Open Access Library Journal,
Vol.12 No.7,
July
11,
2025
ABSTRACT: Background and Aim: Colorectal anastomosis is a necessary surgical procedure in many medical cases. Anastomosis Leakage (AL) is a serious complication that can lead to severe infections and even the need for additional surgeries. Preventing leakage requires precise techniques and innovative methods to enhance tissue healing and improve surgical outcomes. Using Platelet-Rich Plasma (PRP) is a modern approach aimed at reducing leakage following low anterior resection for rectal cancer. Materials and Methods: The sample consisted of 60 patients with a mean age of 60.28 years who underwent open low anterior resection of rectal tumors. Platelet-rich plasma was injected into the anastomotic line in the intervention group, while normal saline (NS) was used in the control group. The results of the two groups were compared in terms of the incidence of anastomotic leakage. Results: Leakage occurred in 4 patients, representing 6.7% of the sample. The results showed that PRP injection was statistically significant when compared to the Control group. Leakage did not occur in any of the platelet-rich plasma patients, while it occurred in 4 patients in the control group, representing 13.3%. Conclusion: Application of Platelet-Rich Plasma injections into the colorectal anastomosis line reduced the incidence of anastomotic leakage following low anterior resection for rectal cancer from 13.3% to 0%.