TITLE:
Follow-Up of HPV Clearance after LEEP Conization and Vaporization for CIN2+, and Vaporization for VaIN2
AUTHORS:
Kenji Niwa, Saki Tsurue, Rui Kyogoku, Masanori Isobe, Yoh Hayasaki, Sakae Mori, Keigo Kuwabara, Kentaro Niwa, Takuji Tanaka
KEYWORDS:
HPV, CINs, LEEP Conization, Vaporization, VaIN
JOURNAL NAME:
Open Journal of Pathology,
Vol.15 No.3,
July
8,
2025
ABSTRACT: LEEP conization with vaporization was performed for 86 CIN2+ cases. Our data suggest that combining LEEP conization and vaporization results in a higher estimated cumulative HPV clearance rate than LEEP alone. The clearance rate tended to be better in younger patients. Vaporization could provide a promising therapeutic option for VaIN2 associated with high-risk HPV infection. Treatment of CIN2+ and VaIN2 using ball electrode vaporization and LEEP conization appears feasible and effective, even in settings lacking specialized surgical devices. After conservative treatment of CINs or VaIN, HR-HPV persists in some cases even in the NILM state without dysplasia, and long-term follow-up is needed.