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Dileep, V., Boix, C.A., Mathys, H., Marco, A., Welch, G.M., Meharena, H.S., et al. (2023) Neuronal DNA Double-Strand Breaks Lead to Genome Structural Variations and 3D Genome Disruption in Neurodegeneration. Cell, 186, 4404-4421.e20.
https://doi.org/10.1016/j.cell.2023.08.038

has been cited by the following article:

• TITLE: Alzheimer’s Disease and Oxidative Stress

  AUTHORS: Shaden Alharbi, Noorah Saleh Al-Sowayan

  KEYWORDS: Alzheimer’s Disease, Oxidative Stress, Mitochondrial Dysfunction, Amyloid Beta, Tau Protein

  JOURNAL NAME: Advances in Aging Research, Vol.14 No.4, June 30, 2025

  ABSTRACT: Alzheimer’s disease (AD) is a progressive neurodegenerative condition marked by synaptic loss, memory decline, and brain atrophy. Oxidative stress plays a pivotal role in the pathogenesis of AD by driving mitochondrial dysfunction, lipid peroxidation, and tau protein hyperphosphorylation. This review discusses the three main pathways through which oxidative stress contributes to AD progression: mitochondrial damage, macromolecule peroxidation, and neuroinflammation. Understanding these mechanisms is essential for identifying therapeutic strategies aimed at disrupting this vicious cycle and mitigating AD development.