TITLE:
A Novel Capillary Zone Electrophoresis Technique for Pharmacokinetic Studies on Porphyrin-C60 Based Neuroprotectors. Preliminary Report
AUTHORS:
Alexander Bukhvostov, Anna Semenova, Olga Kamkina, Stanislav Arkhangelskiy, Dmitry A. Kuznetsov
KEYWORDS:
Neuroprotectors, Porphyrin-Fullerenes, Ischaemic Brain Stroke, Preclinical Trial, Capillary Zone Electrophoresis (CZE)
JOURNAL NAME:
Pharmacology & Pharmacy,
Vol.16 No.6,
June
18,
2025
ABSTRACT: A novel, fast-n-reliable, Quartz capillary silica zone electrophoresis required to upgrade an arsenal of analytical tools for current pharmacokinetics studies on porphyrin-fullerene nanoparticles has been proposed. The fullerene(C60)-tetra(p-hydroxyphenyl)porphyrin structures, known for their capabilities to paramagnetic 25Mg2+ delivery, were found quantitatively detectable in a total rat brain cytosol (S125) fraction, once these nanocationites administered in a single, either 1.0 mg/kg or 20.0 mg/kg, i.v. injection followed by 12 hrs long animal-drug exposition time. Driven by pressing needs in ongoing preclinical trial platform developments, the CZE track proposed might make an impact on both convenience and efficiency of pharmacokinetic estimate of medicinal nanocationites.