Article citationsMore>>

Amirshahi, N., Alyautdin, R.N., Sarkar, S., Rezayat, S.M., Orlova, M.A., Trushkov, I.V., et al. (2008) Fullerene-Based Low Toxic Nanocationite Particles (Porphyrin Adducts of Cyclohexyl Fullerene-C₆₀) to Treat Hypoxia-Induced Mitochondrial Dysfunction in Mammalian Heart Muscle. Archives of Medical Research, 39, 549-559.
https://doi.org/10.1016/j.arcmed.2008.05.007

has been cited by the following article:

• TITLE: A Novel Capillary Zone Electrophoresis Technique for Pharmacokinetic Studies on Porphyrin-C60 Based Neuroprotectors. Preliminary Report

  AUTHORS: Alexander Bukhvostov, Anna Semenova, Olga Kamkina, Stanislav Arkhangelskiy, Dmitry A. Kuznetsov

  KEYWORDS: Neuroprotectors, Porphyrin-Fullerenes, Ischaemic Brain Stroke, Preclinical Trial, Capillary Zone Electrophoresis (CZE)

  JOURNAL NAME: Pharmacology & Pharmacy, Vol.16 No.6, June 18, 2025

  ABSTRACT: A novel, fast-n-reliable, Quartz capillary silica zone electrophoresis required to upgrade an arsenal of analytical tools for current pharmacokinetics studies on porphyrin-fullerene nanoparticles has been proposed. The fullerene(C60)-tetra(p-hydroxyphenyl)porphyrin structures, known for their capabilities to paramagnetic 25Mg2+ delivery, were found quantitatively detectable in a total rat brain cytosol (S125) fraction, once these nanocationites administered in a single, either 1.0 mg/kg or 20.0 mg/kg, i.v. injection followed by 12 hrs long animal-drug exposition time. Driven by pressing needs in ongoing preclinical trial platform developments, the CZE track proposed might make an impact on both convenience and efficiency of pharmacokinetic estimate of medicinal nanocationites.