TITLE:
Case Analysis and Management Strategies of Glucocorticoid-Induced Metabolic Syndrome during Pregnancy
AUTHORS:
Li Tang, Weihua Yang, Qiuping Wang
KEYWORDS:
Gestational Metabolic Syndrome, Glucocorticoids, Metabolic Disorders, Case Report, Management Strategies
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.13 No.6,
June
6,
2025
ABSTRACT: Gestational Metabolic Syndrome (GMS) is a unique cluster of metabolic abnormalities characterized by pre-pregnancy overweight/obesity, dysregulated glucose/lipid metabolism, and elevated blood pressure, significantly increasing risks of adverse pregnancy outcomes and long-term maternal-fetal cardiovascular diseases. This article reports a case of a 36-year-old woman with gestational diabetes mellitus (GDM) who developed acute GMS following dexamethasone administration for threatened preterm labor. The patient developed acute metabolic decompensation 24 hours post-dexamethasone administration, with fasting blood glucose peaking at 13.3 mmol/L and triglycerides exceeding 18.2 mmol/L. Multidisciplinary intervention resulted in favorable maternal and neonatal outcomes. This case highlights the importance of individualized monitoring and early intervention to mitigate metabolic decompensation risks in GDM patients receiving glucocorticoid therapy.