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Musunuru, K., Chadwick, A.C., Mizoguchi, T., Garcia, S.P., DeNizio, J.E., Reiss, C.W., et al. (2021) In Vivo CRISPR Base Editing of PCSK9 Durably Lowers Cholesterol in Primates. Nature, 593, 429-434.
https://doi.org/10.1038/s41586-021-03534-y

has been cited by the following article:

• TITLE: CRISPR-Cas9 and beyond: Expanding the Frontiers of Gene Editing

  AUTHORS: Shuqi Pang, Jingran Qu

  KEYWORDS: Gene Editing, CRISPR-Cas Systems, Medical Applications, Ethical Considerations

  JOURNAL NAME: Advances in Bioscience and Biotechnology, Vol.16 No.5, May 30, 2025

  ABSTRACT: Gene editing technology, which allows for precise modifications to an organism’s genome, has emerged as a transformative tool in genetic engineering. This review introduces the fundamental concepts and mechanisms of gene editing, with a particular emphasis on CRISPR-Cas systems. The principles and methods used in the development and optimization of gene editing tools, including base editing and prime editing, are discussed. The review also summarizes the applications of gene editing in medicine, agriculture, and biotechnology, highlighting its potential to address complex biological challenges. Finally, the review outlines the current challenges and ethical considerations in the field of gene editing research.