TITLE:
Spastic Tetraparesis Due to CIDP with Nerve Root Hypertrophy—A Case Report and Literature Review
AUTHORS:
Ouafae El Hayani, Maria Benabdeljlil, Wadi Bnouhanna, Mounia Rahmani, Leila Errguig, Nezha Birouk, Saadia Aidi
KEYWORDS:
CIDP, Nerve Roots Hypertrophy, Spinal Cord Compression
JOURNAL NAME:
Open Access Library Journal,
Vol.12 No.5,
May
29,
2025
ABSTRACT: Chronic inflammatory demyelinating polyneuropathy (CIDP) with nerve root hypertrophy is a relatively common association, reported in approximately 16 - 54% of cases based on imaging studies. However, it may present a diagnostic challenge, particularly in atypical clinical presentations. We report the case of a 43-year-old patient diagnosed with CIDP who presented with pyramidal syndrome in the lower limbs. Spinal MRI revealed marked hypertrophy of the nerve roots, underscoring the critical role of imaging in supporting the diagnosis and excluding differential diagnoses. Treatment with rituximab, an anti-CD20 monoclonal antibody, has shown promising outcomes in cases of CIDP resistant to conventional therapies, leading to significant clinical improvement and sustained remission in many reported cases, including ours.