TITLE:
Kinetic Evolution of C-Reactive Protein as a Function of Drug Molecule Intake in Patients with Tuberculosis in the Sédhiou Health District (Sénégal)
AUTHORS:
Amadou Bouye Seydi, Nadina Zuleika Leite, Fodé Kaba Seydi, Sadio Déme, Wally Mbodji, Pape Mbacké Sembéne
KEYWORDS:
CRP, Tuberculosis, Sédhiou Health District, Sénégal
JOURNAL NAME:
Open Journal of Applied Sciences,
Vol.15 No.5,
May
26,
2025
ABSTRACT: C-Reactive protein (CRP) is a protein of the inflammatory reaction whose name is linked to its property of being precipitable by a pneumococcal polysaccharide of type C in the presence of ionized calcium. In this prospective study carried out in the health district of Sédhiou, we try to evaluate the impact of taking the anti-tuberculosis treatment molecule in patients with tuberculosis combined with the evolutionary monitoring over time of CRP. The values of the indicator of inflammation or infection were carried out by an A15 biochemical automaton on 30 sick subjects and 20 healthy carriers as a comparative control. The results obtained in patient input data on average give in CRP a value of 93.56 ± 5.71 mg/l, which shows a real infection in the subjects studied then the weight as an illustrative element of the body mass deficit is translated on average with a value of 49.55 ± 1.81 kg and finally the temperature which oscillates with a value of 39.95˚C ± 0.58˚C, which actually shows the feverish state of the patients involved. Moreover, the taking of medication carried out in accordance with the established treatment gives quite encouraging results through the drastic drop in the entry CRP with a value turning to 6.30 ± 1.56 mg/l, leading to a parallel increase in weight with an average value of 60.40 ± 2.76 kg and suddenly a significant drop in temperature with an average of 36.19˚C ± 0.43˚C. Analysis of variance according to the Kruskal-Wallis test (P =