TITLE:
Enhanced Regeneration of Periodontal Tissues Using Low Molecular-Weight Hyaluronic Acid Combined with Radon-Rich Mineral Water from Tskaltubo
AUTHORS:
Gibishvili Ani, Sheyiladze Zurab, Chiqobava Sofo
KEYWORDS:
Periodontal Diseases, Chronic Inflammation, Tissue Destruction, Hyaluronic Acid (HA), Glycosaminoglycan, Periodontal Therapy, Hydrating Properties, Anti-Inflammatory Properties, Regenerative Properties, High-Molecular-Weight HA
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.13 No.5,
May
26,
2025
ABSTRACT: Periodontal diseases, characterized by chronic inflammation and progressive tissue destruction, remain a major global public health concern. Hyaluronic acid (HA), a naturally occurring glycosaminoglycan, has emerged as a promising agent in periodontal therapy due to its hydrating, anti-inflammatory, and regenerative properties. This study investigates the therapeutic efficacy of combining low-molecular-weight hyaluronic acid (HA) with radon-rich mineral water from Tskaltubo in the non-surgical treatment of mild Stage 1 chronic periodontitis. Thirty patients were enrolled and divided into two groups: one receiving conventional HA therapy and the other receiving HA in conjunction with radon water rinses. Clinical assessments, including oral hygiene index (OHI-s), bleeding on probing (BOP), and microvascular perfusion via Doppler ultrasonography, were performed at baseline, one week, and one month post-treatment. Both groups demonstrated clinical improvement, but the combination group showed more rapid and sustained reductions in inflammation, bleeding, and improved gingival microcirculation. The results suggest that radon water may potentiate the regenerative and anti-inflammatory properties of HA, supporting its potential as an effective adjunct in periodontal therapy.