TITLE:
Diagnosis and Management of Cardiac Amyloidosis: The Role of Multimodal Imaging—A Mini Review
AUTHORS:
Camila Ponce-Acosta, Maria Jose Santa-Ana-Bayona, Gilberto H. Acosta-Gutiérrez, Pavel Martinez-Dominguez, Santiago Luna-Alcala, Alfonso Gonzalez-Trejo, Hugo A. Valencia-Hernandez, Enrique C. Guerra, Nilda Espinola-Zavaleta
KEYWORDS:
Amyloid, Echocardiography, Diastolic Dysfunction, Cardiac Infiltration
JOURNAL NAME:
World Journal of Cardiovascular Diseases,
Vol.15 No.5,
May
23,
2025
ABSTRACT: Cardiac amyloidosis is a disease characterized by the deposition of misfolded proteins in the myocardium, leading to restrictive cardiomyopathy. It comprises two subtypes: immunoglobulin light chain cardiac amyloidosis (AL) and transthyretin cardiac amyloidosis (ATTR). ATTR is classified as wild-type (wtATTR) and hereditary (hATTR), depending on the presence or absence of a transthyretin (TTR) genetic mutation. The diagnosis of cardiac amyloidosis is challenging due to nonspecific symptoms with other cardiac conditions, often resulting in misdiagnosis. This mini review provides an in-depth analysis of cardiac amyloidosis, focusing on its subtypes, clinical manifestations, diagnostic multimodal imaging, and recent therapeutic advancements.