TITLE:
Microangiopathic Hemolytic Anemia and Diffuse Bone Metastasis by Signet Ring Cell Adenocarcinoma
AUTHORS:
Andrés J. Muñoz Martín, Pilar García Alfonso, María Carmen Riesco Martínez, Virginia Martínez Marín, Yolanda Jerez Gilarranz, Rebeca Mondejar Solís, Miguel Martín Jiménez
KEYWORDS:
Microangiopathic Haemolytic Anemia, Gastric Cancer, Paraneoplastic Syndrome, Chemotherapy, Signet Ring Cell Adenocarcinoma?
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.1 No.2,
June
29,
2010
ABSTRACT: Microangiopathic hemolytic anemia (MAHA) is a rare paraneoplastic syndrome and is typically associated with gastric adenocarcinoma. We report a 47-year-old woman who presented with asthenia, lower back pain and bleeding. Twelve years ago the patient underwent total gastrectomy due to gastric adenocarcinoma and achieved complete remission. The patient was diagnosed with MAHA and diffuses bone metastasis of signet ring cell adenocarcinoma of unknown origin and was treated successfully with polichemotherapy based on cisplatin and 5-fluorouracil.x