TITLE:
Advancements in Venous Thromboembolism Management: Insights from Diverse Interventions and Patient Populations—An Integrative Review
AUTHORS:
Manuela Reinert Korsic, Paola Rodrigues de Figueredo Anastasio, Diego Ferreira de Andrade Garcia, Gabriel Trindade Barreiro
KEYWORDS:
COVID-19, Interventional Strategies, Patient Outcomes, VTE Management
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.13 No.4,
April
30,
2025
ABSTRACT: Introduction: Venous thromboembolism (VTE), encompassing deep vein thrombosis (DVT) and pulmonary embolism (PE), poses a significant health burden worldwide, leading to considerable morbidity and mortality. Effective prevention and management strategies for VTE are critical, especially given the associated risk factors and implications, including those linked with COVID-19. Timely diagnosis and intervention play pivotal roles in mitigating the impact of VTE on patient outcomes. Method: This integrative review aimed to synthesize findings from studies investigating interventions for VTE prevention and management. A comprehensive search strategy was employed to identify relevant literature, and data analysis involved descriptive statistics, comparative analysis of intervention effectiveness, and qualitative synthesis to identify common themes and trends across studies. Results: The review included studies examining diverse interventions for VTE prevention and management. These interventions ranged from routine duplex ultrasound screening to novel mechanical compression devices and oxygen therapy in intermediate-risk acute PE. Through the studies, interventions demonstrated efficacy in reducing VTE rates, improving compliance, and enhancing patient outcomes. Notable findings included the significant reduction in VTE rates with fondaparinux combined with intermittent pneumatic compression compared to IPC alone and the improved compliance with mechanical prophylaxis using novel mechanical compression devices. Conclusion: The review underscores the importance of diverse interventions in the prevention and management of VTE. While the evidence supports the effectiveness of these interventions, further research, including larger-scale trials, is warranted to validate findings and optimize patient care. This multidisciplinary approach to VTE management reflects a continued commitment to improving outcomes and addressing the global burden of this condition.