TITLE:
Research Progress of CENPA and Cancer
AUTHORS:
Fengjing Nong, Lixia Luo, Rongbin Chen, Cheng Lu, Jiahui Wu, Guoli Hu, Jin Liu
KEYWORDS:
Centromere, Centromere Protein A, Cancer, Chromosomal Instability
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.13 No.4,
April
22,
2025
ABSTRACT: Abnormal cell division leading to chromosomal instability is a hallmark of cancer development. Accurate chromosome classification Lysis plays an important role in cell division, and the centromere is the key to accurate chromosome separation. Centromeric protein A CENPA is a centromere-specific histone H3-like variant gene and is also the most studied in the centromere protein family. A wide range of factors are overexpressed in various cancers. Overexpression of CENPA may lead to centromere heterochromatin along chromosome arms. Diffusion leads to microtubule kinetochore anchoring defects, ultimately resulting in genomic instability. Therefore, exploring the relationship between CENPA overexpression and the relationship between cancer progression is of great significance for finding new targeted treatment methods.