TITLE:
Predictive Value of Antimüllerian Hormone (AMH) and Other Predictors in the Diagnosis of Micropolycystic Ovary Syndrome in Infertile Patients from Butembo in the Democratic Republic of Congo
AUTHORS:
Patrick Batakuya Magala, Jean-Jeannot Juakali Sihalikyolo, Noel Labama Otuli, Jean Didier Bosenge Nguma, Philémon Mumbere Matumo, Etienne Kakule Ndungo, Albain Baraka Munyanderu, Olivier Mumbere Mulisya, Antoine Modia O’yandjo, Emmanuel Komanda Likwekwe, Gédéon Katenga Bosunga
KEYWORDS:
Predictive Value, AMH, Other Predictors, MPCOS, Infertility, Butembo
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.15 No.4,
April
21,
2025
ABSTRACT: Introduction: Micropolycystic ovary syndrome (MPCOS) is one of the main causes of female infertility worldwide. The aim of the study is to determine the predictive value of AMH and other predictors in the diagnosis of MPCOS in the city of Butembo. Material and methods: This was a cross-sectional, analytical, multi-site study conducted in the town of Butembo on 89 infertile patients with MPCOS, married, aged 20 to 45, without hyperprolactinaemia, selected according to the Rotterdam criteria of 2003; 89 infertile patients without MPCOS were matched. Data analysis was performed using R software version 4.4.1. Results: The area under the ROC curve was 0.845 with a sensitivity of 79.8%, a specificity of 76.4% and the best cut-off value for AMH to predict the diagnosis of MPCOS was 5.8 ng/l. In multivariate analysis, AMH (ORa = 1.30 [95% CI = 1.20 - 1.42], p 2 (ORa = 1.17 [95% confidence interval = 1.06 - 1.30], p = 0.002) and testosterone in ng/l (OR = 2.02 [95% confidence interval = 1.25 - 4.00], p = 0.012). Conclusion: AMH proved to be a good predictor of MPCOS in our context, with satisfactory sensitivity, specificity, PPV and NPV. The best threshold value for AMH to predict the diagnosis of MPCOS is 5.8 ng/l.