TITLE:
Synthesis, Crystal Structure of Molecular Salts of 1-Phenylethanamine
AUTHORS:
Chenyu Ruan, Panyue Cao, Ziyi Zhang, Chengjun Jiang
KEYWORDS:
Synthesis, Crystal Structure, Molecular Salts
JOURNAL NAME:
Open Access Library Journal,
Vol.12 No.4,
April
10,
2025
ABSTRACT: Molecular salts, specifically 1-phenylethan-1-aminium 4-hydroxy-3-methoxybenzoate (1), 1-phenylethan-1-aminium 4-hydroxy-3,5-dimethoxybenzoate (2), and 1-phenylethan-1-aminium 3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate (3), were successfully synthesized. The structures of [C8NH12]+[C8H7O4]−(1), [C8NH12]+[C9H9O5]−(2), and [C8NH12]+[C10H9O4]−(3) were confirmed through single crystal X-ray diffraction, revealing that they belong to the tetragonal and monoclinic crystal systems. This synthesis methodology underscores the effectiveness of salt formation as a strategy in crystal engineering to modulate physicochemical properties, which may enhance separation efficiency and broaden applicability in pharmaceutical or industrial contexts.