TITLE:
Lifeceramics-Treated Water Improves Serum Lipid Profile in Hyperlipidaemic Rats
AUTHORS:
Jingyao Yu, Xiaobo Tong, Kuihua Li, Atsushi Suzuki, Kazuko Kita, Nobuo Suzuki
KEYWORDS:
Lifeceramics, Hyperlipidaemia, Serum Lipid Profile, Anti-Oxidant Capacity, Inflammatory Response
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.13 No.4,
April
10,
2025
ABSTRACT: Metabolic disorders such as hyperlipidaemia can be alleviated by drinking water. This study investigated whether lifeceramics (LC)-treated water (LC water) could improve hyperlipidaemia in rats. The LC water was prepared by mixing distilled water with LC particles composed of zeolite and oyster shells. Hyperlipidaemia was induced in rats via gavage with a high-calorie diet (HCD) rich in fat and sugar. The HCD-fed rats were classified into four groups: distilled water-drinking hyperlipidaemia group (hyper LP), low-dose LC water-drinking group (HCD + low LC), high-dose LC water-drinking group (HCD + high LC), and atorvastatin (ATS, a lipid-regulating drug) solution-drinking group (HCD + ATS). Control rats were fed a normal diet and distilled water. All rats were gavaged daily with diet and drinking water, and biochemical indices related to lipid metabolism, oxidative stress, and inflammation were measured after 20 weeks. Notably, higher serum lipid levels, including total cholesterol, triglycerides, and low-density lipoprotein cholesterol, were observed in the hyper-LP rats than in the control rats. However, the LC water-drinking rats exhibited lower serum lipid levels than the hyper-LP rats, as did the HCD + ATS rats. Serum catalase activity and glutathione levels increased and decreased, respectively, in the hyper-LP rats compared with those in the control rats but recovered to around the control levels in the HCD + high LC and HCD + ATS rats. Furthermore, serum tumour necrosis factor-α and adiponectin levels in the hyper-LP rats were increased and decreased, respectively, compared with those in the control rats, whereas their levels recovered to around the control levels following administration of the high or low dose of LC. Therefore, LC water can improve lipid metabolism dysfunction, anti-oxidant capacity, and inflammatory responses in hyperlipidaemic rats.