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Calienni, M.N., Temprana, C.F., Prieto, M.J., Paolino, D., Fresta, M., Tekinay, A.B., et al. (2017) Nano-Formulation for Topical Treatment of Precancerous Lesions: Skin Penetration, in Vitro, and in Vivo Toxicological Evaluation. Drug Delivery and Translational Research, 8, 496-514.
https://doi.org/10.1007/s13346-017-0469-1

has been cited by the following article:

• TITLE: Keratinocyte Biocompatibility of Biogenic Iron Nanoparticles

  AUTHORS: Eliana Daniela Lopez Venditti, Pamela Soledad Bustos, María Natalia Calienni, Jorge Montanari, Paulina Laura Paez, Patricia Angélica Barril, María Gabriela Paraje, Natalia Guiñazú

  KEYWORDS: Iron Nanoparticles, E. coli, Biosynthesis, Keratinocytes, Toxicology

  JOURNAL NAME: Journal of Biomaterials and Nanobiotechnology, Vol.16 No.1, January 30, 2025

  ABSTRACT: Iron nanoparticles (FeNPs) are promising candidates for medical purposes, including topical dermatological applications and skin absorption. This research investigated whether biologically synthesized FeNPs display potential toxic effects in human keratinocytes in vitro. Cell cultures were performed with the HaCaT keratinocyte cell line, which was exposed to FeNPs (0 - 214 µg/mL) for 4 and 24 h. Cell viability, reactive oxygen species production, cellular antioxidant components, and wound healing assays were analyzed. FeNPs did not alter the morphology of HaCaT cells, although low cellular cytotoxicity at the highest concentration was observed. The 214 µg/mL condition also altered cell migration as well as increased reactive oxygen species production. The obtained results have shown that biosynthetic FeNPs display low keratinocyte toxicity and could be explored as promising candidates to be used in local treatments as conjugates for drug delivery systems.