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Hanamsagar, R., Alter, M.D., Block, C.S., Sullivan, H., Bolton, J.L. and Bilbo, S.D. (2017) Generation of an Anti-Inflammatory Microglial Phenotype Is Contingent on IRF4-Mediated Signaling. Brain, Behavior, and Immunity, 60, 1-13.

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• TITLE: The Role of Microglia in Pediatric Neurological Disorders

  AUTHORS: Harmehar Kaur

  KEYWORDS: Microglia, Pediatric Neurology, Autism Spectrum Disorder, Epilepsy, Neuroinflammation, Neurodevelopment

  JOURNAL NAME: Neuroscience and Medicine, Vol.16 No.1, March 13, 2025

  ABSTRACT: Microglia, the central nervous system’s resident immune cells, play a pivotal role in brain development and function, particularly in pediatric neurological disorders. This review explores the molecular mechanisms underlying microglial dysfunction in conditions such as autism spectrum disorder, epilepsy, and juvenile neurodegenerative diseases, emphasizing their age-dependent roles. Therapeutic strategies targeting microglial activity are discussed, highlighting the need for precise, age-appropriate interventions to mitigate neurodevelopmental deficits and improve outcomes for affected children.