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Kulmala, P., Savola, K., Petersen, J.S., Vahasalo, P., Karjalainen, J., Lopponen, T., Dyrberg, T., Akerblom, H.K. and Knip, M. (1998) Prediction of insulin-dependent diabetes mellitus in siblings of children with diabetes. A population-based study. The Childhood Diabetes in Finland Study Group. The Journal of Clinical Investigation, 101, 327-333. doi:10.1172/JCI119879

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• TITLE: Reduced endogenous insulin secretion in diabetic patients with low-titer positive antibodies against GAD

  AUTHORS: Yuichiro Takeuchi, Hiroyuki Ito, Koshiro Oshikiri, Shinichi Antoku, Mariko Abe, Mizuo Mifune, Michiko Togane, Masahiro Kato

  KEYWORDS: GAD Antibody; Endogenous Insulin Secretion; Urinary C-Peptide; SPIDDM; LADA

  JOURNAL NAME: Journal of Diabetes Mellitus, Vol.2 No.1, February 22, 2012

  ABSTRACT: Aim: To investigate the clinical characteristics of diabetic patients with a low-titer positive for the anti-glutamic acid decarboxylase 65 antibody (GAD antibody). Methods: The subjects were 420 diabetic inpatients. The endogenous insulin secretion was estimated on the basis of the C-peptide immunoreactivity from a 24 h urine collection (uCPR). Clinical variables were compared between patients negative for the GAD antibody (GAD antibody titer