TITLE:
Severe Malaria: The Role of Rapid Diagnostic Tests in Children Who Have Previously Received Presumptive Antimalarial Treatment
AUTHORS:
Aymar Pierre Gildas Oko, Judicaël Kambourou, Neli Yvette Ngakengni, Laeticia Lombet, Lynda Tchidjo Ngamo, Georges Marius Moyen
KEYWORDS:
Presumptive Treatment, Severe Malaria, Rapid Diagnostic Tests, Children
JOURNAL NAME:
Open Journal of Pediatrics,
Vol.15 No.2,
March
6,
2025
ABSTRACT: Background: Diagnosis of severe malaria by microscopy can be challenging in children who have previously received presumptive antimalarial treatment. Objective: To analyse the value of rapid diagnostic tests (RDTs) in the diagnosis and management of severe malaria in children who have received incomplete presumptive antimalarial treatment prior to admission. Methods: This was a prospective study which was carried out from December 2021 to April 2022 in the paediatric intensive care unit. Children admitted with suspected severe malaria and who had received incomplete presumptive antimalarial treatment prior to admission were included exhaustively. Microscopic examination of blood smears and RDTs was performed on all children. The p-value was set at 5% and the confidence interval at 95%. Results: In total, 97 (66.0%) of the 147 children admitted for suspected severe malaria met the inclusion criteria, including 49 (50.5%) girls. The median age was 48 months [IQR: 33.5 - 100.5]. The number of confirmed cases of severe malaria by TBS was 26 (26.8%) versus 84 (86.6%) by RDTs (p Conclusion: The irrational use of antimalarial drugs remains common, making it difficult to diagnose severe malaria by microscopy. In these conditions, malaria RDTs can provide a reasonable alternative for better case identification.