TITLE:
Analysis of the Physicochemical Stability of Pickering Emulsions with Eudragit® RS100
AUTHORS:
Papa Mady Sy, Alphonse Rodrigue Djiboune, Sidy Mouhamed Dieng, Anne Dominique Niamké, Mari Alexia Touré-Tiglinatiénin, Boucar Ndong, Louis Augustin Diaga Diouf, Gora Mbaye, Mamadou Mbodj, Mounibé Diarra
KEYWORDS:
Physicochemical Stability, Emulsion, Pickering, Eudragit® RS100
JOURNAL NAME:
Open Journal of Biophysics,
Vol.15 No.2,
February
26,
2025
ABSTRACT: This work focuses on the stabilization of an oil phase (ORO® palm oil from Elaeis guineensis) using Eudragit RS100, thus creating a Pickering emulsion with water containing PEG 6000 as the dispersing phase. Ramsden then Pickering made it possible to understand in their work the role that solid particles can play in stabilizing the interfaces between two immiscible fluids. From these solid particles, we can formulate emulsions called Pickering emulsions. For more than a century, scientists have been increasingly interested in these types of emulsions. The stability that can be achieved with these types of emulsion is better compared to emulsions obtained with surfactants. The formulation was carried out using the spontaneous nanoemulsification technique. Physicochemical characterization was carried out using a series of physicochemical tests and surface tension measurements. Droplet size was determined using a Zeiss optical microscope. The direction of the emulsions was determined by conductimetry. The pH and viscosity of the emulsions were also measured. Tensiometry studies were carried out using the rising drop method with a tracker (Teclis, Longessaigne, France). The results showed that the emulsions were of the O/W type and the majority of them remained stable until the end of the tests. The pH measurements revealed an acidic character for all the formulations (pH between 2.7 and 4) and we also observed that the droplet size was controlled by the volume fraction of the dispersed phase. We also observed that the viscosity of the formulations increased as the volume fraction of dispersed phase became greater. This increase occurred rapidly for nanoemulsions and more slowly for emulsions. These Pickering emulsions and nanoemulsions stabilized by an acrylic polymer, in this case, Eudragit RS100, could be used to encapsulate peptides with a view to developing a potential vaccine or pH-dependent pharmaceutical form.