TITLE:
The Crossroads of Neurology and Immunology: Exploring the Intricacies of Neuroimmune Interactions
AUTHORS:
Isra Omar, Ahmed Alakhras, Samahir Mutwali, Moiz Bakhiet
KEYWORDS:
Neuroimmune Interactions, Neuromediators, Synaptic Plasticity, Homeostasis, Immune Modulation
JOURNAL NAME:
World Journal of Neuroscience,
Vol.15 No.1,
February
19,
2025
ABSTRACT: The concept of neuroimmune interactions has shown significant advancements over the years. Modern research has revealed many areas of connection between fields, which were previously viewed as distinct disciplines. For example, the nervous system can sense changes in the external environment and convey these changes through molecules and mediators with receptors in the immune system to modulate immune responses. Neuromediators can act on different receptors in the same group of cells, producing antipodal effects. Identification of the anti-inflammatory role of glucocorticoids highlighted that the body functions properly in an integrated manner. These interactions and crosstalk are not unidirectional, as the immune system can also influence various aspects of the nervous system, such as synaptic plasticity and fever. Strict integration of neuro-immuno-endocrine circuits is indispensable for homeostasis. Understanding these circuits and molecules can lead to advances in the understanding of various immune diseases, which will offer promising therapeutic options.