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Li, L., Liu, D., Chen, T., Wei, C., Qiao, Y., Liu, W., et al. (2024) Hypoxia-Enhanced YAP1-EIF4A3 Interaction Drives Circ_0007386 Circularization by Competing with CRIM1 Pre-mRNA Linear Splicing and Promotes Non-Small Cell Lung Cancer Progression. Journal of Experimental & Clinical Cancer Research, 43, Article No. 200.
https://doi.org/10.1186/s13046-024-03116-6
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TITLE:
Molecular Mechanisms of the CIRBP Family in Tumors: Current Status and Future Perspectives
AUTHORS:
Yu Cai, Tingting Wang, Yuan Zhan
KEYWORDS:
CIRBP Family, Tumors, Molecular Mechanisms, RNA-Binding Proteins, Cellular Stress
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.16 No.2,
February
13,
2025
ABSTRACT: The Cold-Inducible RNA-Binding Protein (CIRBP) family plays a pivotal role in cellular stress responses and tumorigenesis. Recent studies have increasingly highlighted the expression alterations of CIRBP family members across various cancer types and their potential molecular mechanisms. This review provides a comprehensive overview of the structural characteristics and functions of the CIRBP family, alongside their expression profiles in tumors and the regulatory molecular mechanisms involved. By synthesizing current knowledge, this review aims to offer new insights and directions for future cancer therapies, emphasizing the importance of CIRBP proteins in oncological research.