TITLE:
Correlation between Anti Mullerian Hormone (Amh), Antral Follicule Count and the Response to Ovarian Stimulation in Infertile Women in Douala
AUTHORS:
Bilkissou Moustapha, Tatah Humphry Neng, Nancy Elage Munge, Yannick R. Onana, Yaneu Junie Ngaha, Diane Kamdem, Jean Marie Alima, Alphonse Ngalame, Georges Mangala, Astrid Ndolo, Gervais Mounchikpou, Michelle Mendoua, Aimée Timnou Djokam, Tchounzou Robert, Michel Roger Ekono, Henri Essome, Charlotte Nguefack Tchente
KEYWORDS:
Ovarian Stimulation, AMH, AFC, Ovarian Reserve, Correlation and Prediction Value
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.15 No.1,
January
31,
2025
ABSTRACT: Background: The use of assisted reproductive technique (ART) is becoming more common in infertility. During ART most patients undergo ovarian stimulation. In this study we study the correlation between ovarian reserve markers: Anti-Mullerian hormone (AMH) and antral follicle count (AFC), and the response to ovarian stimulation at in vitro fertilization (IVF) centres in Douala Cameroon. Methods: This was a hospital based cross-sectional sectional analytic study carried out over a period of 3 years, 4 months at Clinique de l’Aéroport, Clinique Odyssée and Clinique Urogyn. Inclusion criteria were: Female partners of infertile couples undergoing ovarian stimulation for an in vitro fertilization cycle, patients who had both ovaries and had done either AMH, AFC or both before ovarian stimulation. Patients were divided into three groups based on the number of oocytes retrieved: low ovarian response for ≤3 oocytes, normal ovarian response for 4 - 15 oocytes and high ovarian response for >15 oocytes. Data obtained was analyzed by SPSS version 25.0. Results: The ages of participants ranged from 20 - 4 7 years, with a mean age of 34.11 ± 5.11 years. Most of them had secondary infertility (57.9%). The GnRH antagonist protocol was mainly used, and ovulation was triggered using HCG predominantly. On Multivariate analysis, age and history of PCOS were significantly associated with ovarian response in the low and high ovarian response groups, respectively. Conclusion: AMH has a better predictive value than AFC, however, it is less sensitive but more specific than AFC.