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Chen, H., Detmer, S.A., Ewald, A.J., Griffin, E.E., Fraser, S.E. and Chan, D.C. (2003) Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development. The Journal of Cell Bio- logy, 160, 189-200. doi:10.1083/jcb.200211046

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• TITLE: Interaction between peroxisomes and mitochondria in fatty acid metabolism

  AUTHORS: Françoise Le Borgne, Jean Demarquoy

  KEYWORDS: Peroxisome; Mitochondria; Fatty Acid Metabolism; Beta Oxidation

  JOURNAL NAME: Open Journal of Molecular and Integrative Physiology, Vol.2 No.1, February 17, 2012

  ABSTRACT: Peroxisomes and mitochondria are ubiquitously found organelles. They both are dynamic structures able to divide, to fuse and to undergo autophagic processes. Their activities are dependent on proteins that are, for most (mitochondria) or all (peroxisome) of them, synthesized in the cytosol from the nuclear genome. Nevertheless, the membrane structures and the DNA content differ between these two organelles. Mitochondria possess a small circular genome while peroxisomes don’t. The control of their dynamic is dependent on specific factors even if some of those are able to affect both. These two organelles are metabolically connected: they are both involved in lipid metabolism. They are both able to beta oxidize fatty acids and are implicated in ROS production. However, their precise function in these metabolic pathways and their physiological functions are different. While mitochondrial metabolism is closely related to energy production, peroxisome does not seem to be associated with energy production but with the production of bioactive molecules and in detoxification processes.