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Briggs, C.A., Jennings, R.A., Wade, R., et al. (1999) Crystalline [R-(R*, R*)]-2-(4-Dfluorophenyl)-β,δ-Dihydroxy-5-(1-Methylethyl)-3-Phenyl-4-[(Phenylamino)Carbon-yl]-1H-Pyrrole-1-Heptanoic Acid Hemi Calcium Salt (Atorvastatin): U.S. Patent US5969156A.
https://sc.panda985.com/extdomains/patents.google.com/patent/US5969156A/en

has been cited by the following article:

• TITLE: Effect of Surfactants on the Solubility of Atorvastatin Calcium

  AUTHORS: Gongyi Liang, Weijie Sun, Ziwei Ai, Jupeng Liu, Chenyu Ruan, Chengjun Jiang

  KEYWORDS: Atorvastatin Calcium, Solubility, Ternary Phase Diagram, Surfactant

  JOURNAL NAME: Open Access Library Journal, Vol.12 No.1, January 30, 2025

  ABSTRACT: Atorvastatin calcium (ATC) is a widely prescribed synthetic cholesterol-lowering agent classified as BCS class II. This study aimed to investigate the solubility of ATC in a methanol-water mixture, which was illustrated through a ternary phase diagram. Additionally, the influence of varying concentrations of Tween 20 on the solubility of ATC in this aqueous methanol mixture was examined. ATC exhibits maximum solubility in pure methanol, and the incorporation of surfactants significantly modifies the drug’s solubility profile depending on its concentration.