TITLE:
The Research Progress of CACNA1A in the Pathogenesis of Vestibular Migraine
AUTHORS:
Ziyao Li, Peng Liu
KEYWORDS:
Vestibular Migraine, CACNA1A, Genetic Variants, Calcium Channel, Pathogenesis, Systematic Review
JOURNAL NAME:
Pain Studies and Treatment,
Vol.13 No.1,
January
23,
2025
ABSTRACT: Vestibular Migraine (VM) is a common neurological disorder characterized by recurrent episodes of vertigo and migraine symptoms. The pathogenesis of VM is complex and involves multiple genetic and environmental factors. Recent studies have suggested that the pathogenesis of vestibular migraine may be associated with variations in the CACNA1A gene, which is an important gene target for controlling calcium ion channels. Such variations may further affect the functions of the vestibular nervous system, thereby causing a series of vestibular nervous system-related symptoms. This article will summarize the genetic association studies of vestibular migraine, vestibular function studies, and research on how to establish relevant animal models to illustrate the possible association between CACNA1A variations and the pathogenesis of VM, providing new ideas for clarifying the pathogenesis of VM.