TITLE:
Intraperitoneal Instillation of Dexmedetomidine vs Dexamethasone as Adjuvant to Bupivacaine for Postoperative Pain in Laparoscopic Cholecystectomy, a Randomized Clinical Trial
AUTHORS:
Ayman Mohamady Eldemrdash, Zaher Z. Zaher, Tarek S. Hemaida, Taha T. Dardeer, Hani M. Raslan, Shawky M. Abdelgalil, Mohmed R. Saad, Mohammed S. Aly
KEYWORDS:
Bupivacaine, Dexmedetomidine, Dexamethasone, Laparoscopic Cholecystectomy
JOURNAL NAME:
Open Journal of Anesthesiology,
Vol.15 No.1,
January
24,
2025
ABSTRACT: Background: Intraperitoneal instillation (IPI) of local anesthesia was reported to reduce postoperative pain after laparoscopic surgeries. We aim to evaluate the effectiveness of IPI of bupivacaine + dexmedetomidine versus bupivacaine + dexamethasone on postoperative pain in patients undergoing laparoscopic cholecystectomy (LC). Methods: This randomized clinical trial was carried out on one hundred patients who underwent LC under general anesthesia. Patients were randomly divided into: Group (Dexa): IPI of bupivacaine with dexamethasone and Group (Dexmed): IPI of bupivacaine with dexmedetomidine. Results: The first time to request analgesia was significantly delayed in the dexmed group (P value Conclusions: Intraperitoneal Bupivacaine + Dexmedetomidine provided longer pain-free postoperative duration lower pain score over time, and lesser analgesic consumption.