TITLE:
Protective Effect of Selenium Supplementation on Cerebral Ischemia-Reperfusion Injury after Ischemic Stroke
AUTHORS:
Mingtian Lu, Zehua He, Zhejing Ding, Zhengwei Chen, Tianyang Guan, Zhongliang Li, Guomin Huang, Guangsen Cheng, Shaoqin Liao, Yu Liu
KEYWORDS:
Selenium, Ischemic Stroke, Cerebral Ischemia-Reperfusion Injury, GPx4
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.13 No.1,
January
21,
2025
ABSTRACT: With the wide application of thrombolytic drugs and the advancement of endovascular therapeutic techniques, the recanalization treatment of acute artery occlusion in ischemic stroke (IS) has made a leap forward, but ischemic brain tissues still face ischemia-reperfusion injury after recanalization. Nowadays, effective neurological protective agents still cannot completely resist the multiple damages of ischemia-reperfusion injury. As an iron-dependent mode of programmed cell death, ferroptosis occupies an important position in ischemia-reperfusion injury. Selenium plays a unique protective role in ischemia-reperfusion injury as an active site element in the center of glutathione peroxidase. Therefore, the study mainly aims to review the protective role of selenium in IS and the related mechanisms, as well as the effect of selenium on the risk factors of IS.