TITLE:
Progress in the Regulation of Lipid Metabolism by the Orphan Nuclear Receptor Nur77
AUTHORS:
Hongjie He, Xiaohong Cen, Yejin Liang, Jinmei Zhong, Junhua Deng, Yujie Jiang
KEYWORDS:
Orphan Nuclear Receptor, Nur77, NR4A1, Lipid Metabolism, COPD
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.13 No.1,
January
16,
2025
ABSTRACT: Neuron-derived clone 77 (Nur77) is a member of the NR4A subfamily that plays critical roles in apoptosis, survival, proliferation, autophagy, angiogenesis, inflammatory responses, DNA repair, glycolipid metabolism and energy consumption. The deregulation of Nur77 signalling often relates to various serious diseases, including cancer and non-cancer diseases. A systematic review is necessary for the better understanding of Nur77 in clinical treatment. In this article, we comprehensively conclude the lipid regulation function and expression of Nur77, and its role in COPD. Finally, we prospect that development of drugs and clinical biochemical investigations targeting of Nur77 has considerable potential within healthcare.