TITLE:
Effects of Acetic Acid Bacteria (Gluconacetobacter hansenii GK-1) on Fatigue Induced by Temporary Mental Stress: A Randomized, Double-Blind, Placebo-Controlled Study
AUTHORS:
Wei Wang, Mariko Oe, Mengwei Yuan, Keiko Kuriyama, Yumi Takeda, Mamoru Kimura, Ryosuke Matsuoka, Kiichi Sugiyama, Naoki Miura
KEYWORDS:
Acetic Acid Bacteria, Gluconacetobacter hansenii GK-1, Fatigue, Temporary Mental Stress, Double-Blind Study
JOURNAL NAME:
Food and Nutrition Sciences,
Vol.16 No.1,
January
13,
2025
ABSTRACT: Objective: This study assessed the effects of consuming acetic acid bacteria (Gluconacetobacter hansenii GK-1) for 12 weeks on fatigue induced by temporary mental stress. Methods: This randomized, double-blind, placebo-controlled, parallel-group study included 100 healthy male and female adults aged 20 - 64 years. Participants consumed either the G. hansenii GK-1 supplement (9 × 10⁹ cells/day) or a placebo daily for 12 weeks. The impact of temporary mental stress on fatigue in G. hansenii GK-1 was assessed using a Visual Analog Scale (VAS) before the study began and after 12 weeks of supplementation. Results: Subjective fatigue measured by Visual Analog Scale (VAS) showed a significant decrease in fatigue induced by temporary mental stress after 12 weeks of consumption in the G. hansenii GK-1 group compared with the placebo group. No adverse events were attributed to G. hansenii GK-1. These findings confirm that continuous oral ingestion of G. hansenii GK-1 by healthy Japanese adults reduces feelings of fatigue caused by temporary mental stress.