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Marcinkiewicz, C., Weinreb, P.H., Calvete, J.J., Kisiel, D.G., Mousa, S.A., Tuszynski, G.P. and Lobb, R.R. (2003) Obtustatin: A potent selective inhibitor of alpha1beta1 integrin in vitro and angiogenesis in vivo. Cancer Research, 63, 2020-2023.

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• TITLE: Electroporation and electropermeabilization of lipid bilayer membranes in the course of snakes’ venom intoxication

  AUTHORS: Naira Ayvazyan, Narine Ghazaryan, Naira Zaqaryan

  KEYWORDS: Lipid Bilayer; Electroporation; Viper Venom; Breaking-Potential; Electropermeabilization

  JOURNAL NAME: Journal of Biophysical Chemistry, Vol.3 No.1, February 15, 2012

  ABSTRACT: The present study was undertaken to elucidate how the plastic properties of model membranes from native lipids of different tissues of rats change in the course of Macrovipera lebetina obtuse (MLO), Montivipera raddei (MR) and Naja kaouthia (NK) venoms processing. The presence of viper venom in organism lead to increasing of the electrical resistance of BLMs from liver and muscle lipids approximately on a sequence, while the BLMs from brain lipids has not shown a noticeable differences of plastic properties compare the control. The same concentration of cobra venom leads to decreasing of electrical resistance of BLMs from 1011 Ohm till 108 Ohm. The low concentration of venom leads to appearance of channel activity. Especially it is noticeable in liver lipids in media of bivalen ions.