TITLE:
Experimental Study of the Antitumor Activity of Polymetalacrylates against Animal Transplantable Tumors
AUTHORS:
Larisa A. Ostrovskaya, M. G. Voronkov, D. B. Korman, M. M. Fomina, N. V. Bluhterova, V. A. Rikova, K. A. Abzaeva, L. V. Zhilitskaya
KEYWORDS:
Polymetalcrylates, Antitumor Activity, Transplantable Tumors of Animals
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.1 No.2,
June
29,
2010
ABSTRACT: The antitumor activity of the fourteen polymetalacrylates against two models of murine solid tumors (Lewis lung carcinoma and Acatol adenocarcinoma) as well as the acute toxicity of these compounds has been studied. It was shown that polyacrylates of noble metals (argent, aurum, platinum), namely argacryl (М = Ag), auracryl (М = Au) and platacryl (М = Pt) were the most effective agents among tested compounds against studied tumors. Thus, the tumor growth inhibitory effect of argacryl against Lewis lung carcinoma was equal to 90%, the life-span of treated by this compound animals has increased on 50% in comparison with control. Auracryl induced the inhibition of the Lewis lung carcinoma and Acatol adenocarcinoma development on 60 and 65%, correspondingly and the increasing of the mean life-span of animals with Lewis lung carcinoma on 20% in comparison with control. Platacryl inhibited the growth of Lewis lung carcinoma on 40% increasing the mean life-span of animals on 25% in comparison with control. In this way it was established that argacryl is the agent with the strongest antitumor activity among studied polymetalacrylates. On the basis of obtained data it seems possible to consider polymetalacrylates as a group of agents with the potential antitumor activity suitable for the further deep experimental investigation.