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D. Monleon, V. Esteve, H. Kovacs, J. J. Calvete and B. Celda, “Conformation and Concerted Dynamics of the Integrin-Binding Site and the C-terminal Region of Echistatin Revealed by Homonuclear NMR,” Biochemical Journal, Vol. 387, No. 1, 2005, pp. 57-66. doi:10.1042/BJ20041343

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• TITLE: Antitumor Activity of Disintegrin-Like Components from the Venom of Montivipera raddei

  AUTHORS: Silva Amiryan

  KEYWORDS: Snake Venom, Montivipera raddei (Armenian Viper), Disintegrins, Antitumor Activity

  JOURNAL NAME: Journal of Cancer Therapy, Vol.2 No.5, December 31, 2011

  ABSTRACT: Our findings represent the first report of the antitumor activity of the disintegrin-like components from the venom of Armenian viper (M. raddei). The venom of M. raddei was separated by reverse phase high-performance liquid chroma-tography (RP HPLC), and individual fractions were analyzed for disintegrin activity. Disintegrin-like components from the venom of M. raddei, by blocking integrins on breast cancer cells (MDA-MB-435), not only interferes with adhesion of breast cancer cells to the extracellular matrix, but also inhibits cellular mobility which is essential for cancer invasion. These effects seriously curtail the metastatic capability of the MDA-MB-435 cells.