TITLE:
Antitumor Activity of Disintegrin-Like Components from the Venom of Montivipera raddei
AUTHORS:
Silva Amiryan
KEYWORDS:
Snake Venom, Montivipera raddei (Armenian Viper), Disintegrins, Antitumor Activity
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.2 No.5,
December
31,
2011
ABSTRACT: Our findings represent the first report of the antitumor activity of the disintegrin-like components from the venom of Armenian viper (M. raddei). The venom of M. raddei was separated by reverse phase high-performance liquid chroma-tography (RP HPLC), and individual fractions were analyzed for disintegrin activity. Disintegrin-like components from the venom of M. raddei, by blocking integrins on breast cancer cells (MDA-MB-435), not only interferes with adhesion of breast cancer cells to the extracellular matrix, but also inhibits cellular mobility which is essential for cancer invasion. These effects seriously curtail the metastatic capability of the MDA-MB-435 cells.