TITLE:
Primary Polydipsia and sIDH Type D Due to Water-Electrolytic Disturbance in a Schizophrenic Patient: A Case Report and Systematic Review
AUTHORS:
Bianca F. Pires, Júlia Maria de Oliveira, Guilherme V. Kitayama, Vitória C. Tahan, Flávia R. Darwin, Luiz Antônio L. C. Saraiva, Carolina C. T. Vilarinho, Gabriela B. Dorilêo, João Pedro F. Amaral, Lucas P. B. de Santana, Sarah P. Farid, Tiago V. C. Albuquerque, André B. Villani, Fernanda S. Nascimento, Larissa D. G. Pelegrino, Renato Augusto Tambelli, álvaro Tavares de Figueiredo
KEYWORDS:
Schizophrenia, Psychogenic Polydipsia, Water intoxication, Inappropriate ADH Syndrome
JOURNAL NAME:
Open Journal of Psychiatry,
Vol.15 No.1,
December
31,
2024
ABSTRACT: Introduction: Primary polydipsia, frequently observed in patients with schizophrenia, can cause severe hyponatremia, leading to serious complications. Objective: This study reviews the management and prevalence of psychogenic polydipsia, focusing on treatments and clinical outcomes. Methods: Following the PRISMA guidelines, studies on polydipsia in psychiatric patients were included. Data were extracted from databases such as PubMed and Scopus, and a meta-analysis was performed. Results: Fifteen studies were analyzed, totaling 586 patients. The use of urea was effective in correcting hyponatremia, while antipsychotics showed mixed results. Heterogeneity between studies was moderate (I2 = 56%). Conclusion: Psychogenic polydipsia is a severe condition in schizophrenic patients. The use of urea has shown promise, but further studies are needed to optimize treatments.