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Palermo, G., Campomanes, P., Cavalli, A., Rothlisberger, U. and De Vivo, M. (2014) Anandamide Hydrolysis in FAAH Reveals a Dual Strategy for Efficient Enzyme-Assisted Amide Bond Cleavage via Nitrogen Inversion. The Journal of Physical Chemistry B, 119, 789-801.
https://doi.org/10.1021/jp5052276

has been cited by the following article:

• TITLE: A New Process of Synthesizing Anandamide Derivatives from Arachidonic Acid in the Presence of Boron Catalyst

  AUTHORS: Mohammad Al-Masum, Linda Quinones

  KEYWORDS: Anandamide, Cross-Coupling, Microwave, Alcohol Amines

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.14 No.4, December 23, 2024

  ABSTRACT: Anandamide is part of the cannabinoid group and functions as a neurotransmitter. Anandamide plays a role in depression, pain, appetite, memory, and fertility. Since it is well documented that anandamide analog behaves as probes of the cannabinoid receptor, it is of great interest to find a new method of making new series of anandamide derivatives. Dennis Hall and his group recently reported a direct amidation process of carboxylic acid by ortho-iodo boronic acid. Using ortho-iodo boronic acid as a catalyst, we explore the amidation of arachidonic acid under microwave heating and synthesize anandamide derivatives in high yields.