TITLE:
Progress in the Application of Noninvasive Myocardial Work to Evaluate Chemotherapy-Related Cardiotoxicity
AUTHORS:
Ling Guo, Qiang Zhang, Jinshu Wang, Xinyu Hao
KEYWORDS:
Noninvasive Myocardial Work, Cardiotoxicity, Anthracycline Chemotherapy, Pressure-Strain Loop, Left Ventricular Pressure
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.12 No.12,
December
19,
2024
ABSTRACT: Due to advances in modern tumor treatments, patients can survive long-term. However, cardiotoxicity caused by tumor therapy poses a significant challenge to both physicians and patients. Early detection and accurate assessment of cardiovascular toxicity from tumor therapy are crucial for guiding clinical treatment and improving patient prognosis. A noninvasive myocardial workup can monitor and assess the development of tumor chemotherapy-related cardiotoxicity. In monitoring oncology chemotherapy-related cardiac injury, a significant decrease in left ventricular ejection fraction (LVEF) of left ventricular systolic function (LVSCF) often indicates severe cardiac injury, making it challenging to monitor early cardiac injury. 3D-STI (three-dimensional speckle tracking imaging) can evaluate early cardiac injury, but its load dependence reduces the accuracy of myocardial function evaluation. In contrast, the noninvasive evaluation of myocardial work using left ventricular pressure-strain loops (PSL), which considers both myocardial deformation and left ventricular pressure, avoids the effect of load dependence on myocardial contractile function and improves the accuracy of myocardial function evaluation. This article reviews the noninvasive evaluation of myocardial work to assess cardiotoxicity associated with tumor chemotherapy.